She has gotten more anxious. She used to snuggle down in any available lap, but now gets distressed if you pick her up and she can't sit still in a lap most of the time. Sometimes she just paces in circles for a couple of hours, til she tires herself out, then we put her in her bed and she is quiet for a while. She has good days and bad, but isn't in pain and still eats good. She was never perfect on potty training, but seems to be getting worse. Sometimes when she paces, it is because she needs to go outside but can't seem to tell us that anymore.
Nights have been the hardest. She can't go all night now without needing to go out and was soiling her bed at night. We put a large (St Bernard sized) wire crate in the living room and she sleeps there now. We put disposable doggie potty pads at the front of it and her bed at the back on a raised rubber cushion. That allows her to get up as much as she needs to at night and keeps her bed up where it doesn't get wet--most of the time. I bought 3 small, washable beds at a big box store for $5 each and just swap them out.
She stays there in the daytime now if we have to leave the house. We know she is safe in the crate and we don't have to worry about her trying to get up or down on the couch. Our other doxie has gotten a little aggressive with her as she has declined, which also worries us, so we separate them if we aren't home.
I think the medications are causing the anxiety. She is also more sensitive to cold. There were a couple of really cold mornings (we're talking zero degrees) where she cried like she was in pain when we took her out. She kept lifting her feet up off the snow like it was hurting her. Later in the day, when it warmed up to 40ish, she didn't do that.
We know we will be faced with a hard decision soon, but for now she has more good days than bad, so we will all just cope. She has been part of the family for 12 years and we will see this through with her.